Geminivirus-induced reprogramming of plant defense mechanisms: molecular insights and research frontiers

Abstract

Geminiviruses employ multifunctional protein ammunition to evade robust plant defense pathways. Key viral proteins effectively manipulate host signaling mechanisms to create a permissive environment for viral replication. Rapid evolutionary adaptation of geminiviruses, synergized by the proliferation of insect vectors, creates a challenge for effective disease control. Current plant resistance against geminiviruses primarily relies on antiviral RNA silencing and the localized cell death mechanism as an outcome of the hypersensitive response. To win the escalating arms race between geminivirus manipulation and subsequent plant counteracting strategies and effectively restrict viral invasion, these defense strategies need to be updated or supplemented with novel engineering approaches. In this review, we provide a critical contemporary understanding of viral reprogramming pathways and host counter-defense responses that provide new avenues to improve plant immunity against geminiviruses.