Recent advances in plant-virus interaction with emphasis on small interfering RNAs (siRNAs)

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dc.contributor.authorSharma, Namisha
dc.contributor.authorSahu, Pranav Pankaj
dc.contributor.authorPuranik, Swati
dc.contributor.authorPrasad, Manoj
dc.date.accessioned2015-11-18T08:18:49Z
dc.date.available2015-11-18T08:18:49Z
dc.date.issued2013
dc.description.abstractRegulation of several biological functions in plants has now been known to involve diverse RNA silencing pathways. These vital pathways involve various components such as dsRNA, Dicer, RNA-dependent RNA polymerase and Argonaute proteins, which lead to the production of several small RNAs (sRNAs) varying in their sizes. These sRNAs have significant role in the regulation of gene expression at transcriptional and translational levels. Among them, small interfering RNAs (siRNAs; majorly 21, 22 and 24 nt) have been shown to play an important role in plants' resistance against many viruses by inhibiting the viral gene expression. Furthermore, it has also been highlighted that siRNA-mediated methylation of viral DNA confers resistance to various plant DNA viruses. In this review, we have outlined the recent advances made using the siRNA-mediated antiviral strategy, along with methylation-based epigenetic defensive mechanisms as a protective measure against diverse plant viruses.en_US
dc.description.sponsorshipGrateful thanks are due to the Director, National Institute of Plant Genome Research (NIPGR), New Delhi, India, for providing facilities. The authors work in this area were supported by the core grant of NIPGR. Ms Namisha Sharma acknowledges the award of Junior Research Fellowship from DBT, New Delhi. We would like to thank all the reviewers for their con- structive comments.en_US
dc.identifier.citationMol. Biotechnol. 55(1): 63-77en_US
dc.identifier.doi10.1007/s12033-012-9615-7en_US
dc.identifier.issn1559-0305
dc.identifier.officialurlhttp://link.springer.com/article/10.1007%2Fs12033-012-9615-7en_US
dc.identifier.urihttp://172.16.0.77:8080/jspui/handle/123456789/365
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectPlant virusen_US
dc.subjectHost–virus interactionen_US
dc.subjectGene silencingen_US
dc.subjectSmall RNAen_US
dc.subjectDNA methylationen_US
dc.titleRecent advances in plant-virus interaction with emphasis on small interfering RNAs (siRNAs)en_US
dc.typeArticleen_US

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