Bioefficacy of Sida cordifolia L. phytoextract against foodborne bacteria: optimization and bioactive compound analysis

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dc.contributor.authorKumar, Sachin
dc.contributor.authorKumar, Sandeep
dc.contributor.authorMir, M Amin
dc.contributor.authorVishnoi, Vineet Kumar
dc.contributor.authorPandey, Ashutosh
dc.contributor.authorPandey, Akanksha
dc.date.accessioned2023-10-04T09:23:41Z
dc.date.available2023-10-04T09:23:41Z
dc.date.issued2023
dc.descriptionAccepted date: 3 August 2023en_US
dc.description.abstractAim: To elucidate the antibacterial activity of Sida cordifolia L. phytoextract, evaluate its polyphenol profile and optimize conditions against certain common foodborne bacteria. Methods: After polarity-based sequential extraction, S. cordifolia phytoextracts were tested for antibacterial potential against antibiotic-resistant bacteria. Box-Behnken design was used to optimize several process parameters and ultra-performance liquid chromatography confirmed the phenolic composition of the best possible outcome. Results: Agar well diffusion and MIC/MBC assay confirmed a strong bactericidal effect of ethanolic (SC04-ET) extract against ampicillin and colistin-resistant Escherichia coli, Listeria monocytogenes and Staphylococcus aureus. The direct interactive effect of optimized conditions showed maximum antibacterial performance and ultra-performance liquid chromatography revealed a high amount of phenolic compounds. Conclusion: The results confirmed that ethanolic extract of S. cordifolia has potent bactericidal action against foodborne bacteria.en_US
dc.description.sponsorshipS Kumar and S Kumar wish to acknowledge the academic support of UCOST (Dehradun, India) and the administration of Gurukula Kangri (deemed to be a University; Haridwar, India) for providing facilities.en_US
dc.identifier.citationFuture Microbiology, 18(17): 1235-1249en_US
dc.identifier.issn1746-0913
dc.identifier.issn1746-0921
dc.identifier.otherhttps://doi.org/10.2217/fmb-2023-0064
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/fmb-2023-0064?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.identifier.urihttps://ndkr-library.nipgr.ac.in/handle/123456789/1525
dc.language.isoen_USen_US
dc.publisherFuture Medicine Ltden_US
dc.subjectBox-Behnken designen_US
dc.subjectUPLCen_US
dc.subjectantibacterialen_US
dc.subjectantibiogramen_US
dc.subjectbactericidalen_US
dc.subjectpolyphenolen_US
dc.titleBioefficacy of Sida cordifolia L. phytoextract against foodborne bacteria: optimization and bioactive compound analysisen_US
dc.typeArticleen_US

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