Institutional Publications

Permanent URI for this collectionhttps://ndkr-library.nipgr.ac.in/handle/123456789/11

Browse

Author: search.filters.author.Singh, Vijender

Search Results

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Perspectives of the Artemisia annua dry leaf therapy (ALT) for malaria and of its re-purposement as an affordable cure for artemisinin-treatable illnesses
    (Indian National Science Academy, 2018) Goel, Richa; Kumari, Raj; Singh, Vijender; Kumari, Renu; Srivastava, Suchi; Kumar, Sushil
    Malarial diseases continue to risk the lives of more than 3 billion people in 97 countries in the world, causing sickness in several million people and death to half a million patients. The preponderate malaria causing apicomplexan protozoan parasite species Plasmodium falciparum and Plasmodium vivax have become genetically resistant to most of the approved antimalarial drugs, including the artemisinin-based combination therapies (ACTs). At this time, there is a vigorous need to make enough efforts to meet the challenge of combating multi-drug resistant malaria by (a) speeding up the trials in progress on relatively more effective, new and mechanistically different antimalarial pharmaceuticals, (b) production of effective vaccines against falciparum and vivax malaria, (c) devising of new ways to use the presently available anti-malarials such as by using three-drugs ACTs and by using the different two-drug and three-drug ACTs sequentially, and (d) induction of Artemisia annua dry leaf therapy (ALT) of recent origin, but of ancient precedent, as an effective treatment for acute and complicated malaria. Here, a perspective type review is presented of the: pre-ALT antimalarial drugs, methodology of their usage and consequences of resistance development; safety, efficacy, affordability, quality maintenance and resilience to resistance development aspects of ALT; and possibilities of ALT re-purposement for treating many infectious-metabolic disorder related- and cancerous-diseases. In conclusion, an urgent need is emphasized for pilot studies and clinical trials on ALT to attest its deployment as anti-malarial and cure for diseases beyond malaria.
  • Thumbnail Image
    Item
    Volatile metabolite compositions of the essential oil from aerial parts of ornamental and artemisinin rich cultivars of Artemisia annua
    (Taylor & Francis Group, 2008) Goel, Divya; Mallavarupu, Gopal Rao; Kumar, Sushil; Singh, Vijender; Ali, Mohammed
    The essential oils of the aerial parts (flowers, leaves and stems) of the artemisinin rich cultivar ‘Jeevanraksha’ and artemisinin poor ornamental type cultivar Suraksha of Artemisia annua, grown at New Delhi, were characterized for their metabolite composition by GC and GC/MS analyses. Ninety-seven compounds comprising 91.3% of the total oil of ‘Jeevanraksha’ were identified. Forty-three monoterpenes (56.6%), 32 sesquiterpenes (31.1%), and 2 diterpenes (0.2%) comprised bulk of the oil (87.9%). The oil was devoid of artemisia ketone and contained camphor (13.5%), 1,8-cineole (9.4%), trans-sabinol (7.1%), p-mentha-1(7), 5-dien-2-ol (6.3%), myrcene (4.7%), germacrene D (4.4%), (E)-β-farnesene (3.9%), β-caryophyllene (3.7%), dihydroartemisinic lactone (3.0%) and p-cymene (2.0%) as the major constituents. Eighty-six compounds representing 93.3% of the composition were identified in the Suraksha oil. This oil contained artemisia ketone (47%), 1,8-cineole (8.4%), camphor (5.9%) and α-pinene (5.2%) as the major components. Many compounds were detected in the A. annua oil for the first time. Consistent with hybrid origin of the cultivar ‘Jeevanraksha’, its oil possessed characteristics reported earlier for the corresponding essential oils of the A. annua accessions of Vietnamese origin and North-American accessions.
  • No Thumbnail Available
    Item
    Composition of the essential oil from the roots of Artemisia annua
    (Springer, 2007) Goel, Divya; Goel, Richa; Singh, Vijender; Ali, Mohammed; Mallavarapu, Gopal Rao; Kumar, Sushil
    Upon hydrodistillation, dried roots of Artemisia annua L. cultivar Jwarharti gave a pleasantly fragrant essential oil with a yield of 0.25%. GC and GC–MS analyses of the oil enabled the identification of 52 components representing 83.2% of the oil. The oil was rich in sesquiterpenes and oxygenated sesquiterpenes and had cis-arteannuic alcohol (25.9%), (E)-β-farnesene (6.7%), β-maaliene (6.3%), β-caryophyllene (5.5%), caryophyllene oxide (4.4%) and 2-phenylbenzaldehyde (3.5%) as its major components. The oil was found to possess considerable fumigant activity and ability to repel adult Tribolium castaneum beetles.
  • No Thumbnail Available
    Item
    Essential oils of petal, leaf and stem of the antimalarial plant Artemisia annua
    (Springer, 2006) Goel, Divya; Singh, Vijender; Ali, Mohammed; Mallavarupu, Gopal Rao; Kumar, Sushil
    The chemical composition of the essential oils obtained from petals, leaves and stems of the flowering stage of plants of Artemisia annua cultivar Jwarharti was analyzed by gas chromatography mass spectrometry (GC-MS); 86, 77, and 63 compounds were identified in the leaf, petal, and stem oils, respectively. Large compositional differences were detected between the three oils. The petal and leaf oils were rich in monoterpenes. The stem oil was rich in sesquiterpenes. Camphor, present in the leaf oil, was absent from petal oil.