Institutional Publications

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Author: search.filters.author.Sharma, ManviSubject: search.filters.subject.glucose

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    Arabidopsis target of rapamycin coordinates with transcriptional and epigenetic machinery to regulate thermotolerance
    (Frontiers Media S.A., 2021) Sharma, Mohan; Jamsheer, K.M.; Shukla, Brihaspati Narayan; Sharma, Manvi; Awasthi, Prakhar; Mahtha, Sanjeet Kumar; Yadav, Gitanjali; Laxmi, Ashverya
    Global warming exhibits profound effects on plant fitness and productivity. To withstand stress, plants sacrifice their growth and activate protective stress responses for ensuring survival. However, the switch between growth and stress is largely elusive. In the past decade, the role of the target of rapamycin (TOR) linking energy and stress signalling is emerging. Here, we have identified an important role of Glucose (Glc)-TOR signalling in plant adaptation to heat stress (HS). Glc via TOR governs the transcriptome reprogramming of a large number of genes involved in heat stress protection. Downstream to Glc-TOR, the E2Fa signalling module regulates the transcription of heat shock factors through direct recruitment of E2Fa onto their promoter regions. Also, Glc epigenetically regulates the transcription of core HS signalling genes in a TOR-dependent manner. TOR acts in concert with p300/CREB HISTONE ACETYLTRANSFERASE1 (HAC1) and dictates the epigenetic landscape of HS loci to regulate thermotolerance. Arabidopsis plants defective in TOR and HAC1 exhibited reduced thermotolerance with a decrease in the expression of core HS signalling genes. Together, our findings reveal a mechanistic framework in which Glc-TOR signalling through different modules integrates stress and energy signalling to regulate thermotolerance.
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    The versatile role of glucose signalling in regulating growth, development and stress responses in plants
    (Springer Nature Publishing AG, 2020) Saksena, Harshita B.; Sharma, Manvi; Singh, Dhriti; Laxmi, Ashverya
    Sugars as an energy source and a signalling molecule are indispensible for growth, development and stress responses in plants. Among sugars, glucose (Glc) has been identified to perform a key role in regulating various cellular and developmental processes in plants. This comprehensive review highlights the crosstalk of glucose signalling with auxin, cytokinin and brassinosteroid signalling in controlling several aspects of plant development including root growth deviation, root waving and coiling, lateral root emergence, hypocotyl elongation, etc. through a Hexokinase 1 dependent and independent pathway in Arabidopsis. It also provides an insight on the role of Glc-mediated target of rapamycin signalling in modulating various abiotic stresses like nutrient deficiency stress, heat stress, oxidative stress etc. The review also discusses about sugar inducible FCS-Like Zinc Finger genes in modulating SNF1-related protein kinase 1 signalling to coordinate growth and stress responses in plants. Therefore, glucose signalling in concert with diverse signalling pathways and via regulating certain genes contributes to numerous cellular processes to control development and stress responses in plants.